This course covers all of the major computational tools used in drug development, providing a foundational understanding of the area. This course explores the introduction about bioinformatics study. Retrieval of nucleotide sequences and analysis. Procedure for the submission of nucleotide sequences to NCBI GenBank (Sequin or Bankit) to get NCBI accession number. Sequence homology and its significance. Nucleotide sequence alignment (Global and local), Pairwise and multiple sequence alignment. Multiple sequence alignment and its significance (ClustalX, ClustalW, BioEdit, MEGA4.1) and its application in primer designing. Phylogenetic analysis using MEGA software and Clustal Omega (Distance based and character-based methods) Comparative homology modeling (Swiss Model, Modeler, I-TASSER server etc), Interpretation of 3D structure and its relevance. Introduction to docking: Protein-Ligand Docking, interpretation of dock poses and its application. The question Answers session for each topic will help participants to solve the questions of CSIR-NET, ICMR-JRF, GATE, CUCET, GAT-B etc.